Ellagic Acid Cancer Cure

Ellagic acid can assist in a holistic cancer treatment. Ellagic acid will not cure cancer alone but in combination with other herbs, juices and therapies, ellagic acid will boost cancer treatment effectiveness.

Ellagic acid is a phytochemical found in raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, and other plant foods.

Different researches have found that ellagic acid has antioxidant, apoptotic, anti-inflammatory, chemopreventive, and anticarcinogenic properties. Ellagic acid has also been found to protect normal cells against radiation damage making it a good addition to cancer radiotherapy. Another research found ellagic acid and quercetin to be anticarcinogenic.

Dr. Daniel Nixon, a pioneer in cancer prevention research at the Hollings Cancer Institute in the Medical University of South Carolina, has examined the ability of ellagic acid to prevent colon and cervical cancers from developing. Preliminary evidence generated by his team of researchers has indicated that ellagic acid can slow the proliferation of both human colon and cervical cancer cells grown in experimental systems outside of the body.

These findings have led to the hypothesis that ellagic acid may be useful in humans susceptible to either of these two cancers. While not yet complete, clinical studies are in progress at the Medical University of South Carolina and studies in women susceptible to cervical cancer are under way. The colon trial will measure ellagic acid’s ability to prevent the formation of colon polyps (which may be the precursor to colon cancer) and/or slow the growth of rapidly proliferating colon cells in human papilloma virus which is responsible for this disease.

Following exposure to ellagic acid human cervical cancer cells, infected with the human papilloma virus (HPV), die within several days due to apoptosis.

Ellagic acid is also found to prevent the destruction of a cellular regulatory gene, P53, by HPV oncogenies (genes responsible for cancer induction) in cervical cells. Similar protective effects were observed in breast, pancreas, esophageal, skin, colon, leukemia, and prostate cancer cells exposed to ellagic acid.
The data from Dr. Nixon’s lab and other investigators indicate that ellagic acid activates detoxifying enzymes in the liver resulting in the clearing of cancer-causing chemicals in the serum; prevents the binding of carcinogens to cellular DNA; serves as an antioxidant in the scavenging and clearance of highly destructive oxygen free radicals; induces apoptosis in cancerous cells; and stimulates the immune system for the destruction of cancerous cells. Each of these attributes were found to be important in reducing the incidence of cancer in experimental models.

Finally, while the mechanisms are not yet fully known, research performed in Europe indicate that ellagic acid may also be useful in reducing the incidence of birth defects, promote wound healing, and limit chemically induced liver fibrosis. In addition, some investigators now believe that ellagic acid may be useful in the prevention of heart disease and periodontal disease.

Almost all studies conducted on ellagic acid to date have been done in cell cultures or laboratory animals. Several animal studies have found that ellagic acid can inhibit the growth of tumors of the skin, esophagus, and lung, as well as other tumors caused by carcinogens. Other studies have also found positive effects. Further studies are needed to determine whether these results apply to humans.

In the only study reported thus far in humans, Italian researchers found that ellagic acid seem to reduce the side effects of chemotherapy in men with advanced prostate cancer, although it did not slow disease progression or improve survival. The researchers cautioned that more research would be needed to confirm these results.

The highest levels of ellagic acid are found in raspberries, strawberries, and pomegranates, especially when they are freeze-dried. Extracts from red raspberry leaves or seeds, pomegranates, or other sources are said to contain high levels of ellagic acid and are available as dietary supplements in capsule, powder, or liquid form. The best dose of these preparations is not known.

Ellagic Acid Historical Medical Usage

Ellagic acid was studied in the 1960s mainly for its effects on blood clotting. Early published research on ellagic acid and cancer first appeared in the 1970s and 1980s. With the publication of several small laboratory studies in the mid-1990s, ellagic acid began to be promoted on the Internet and elsewhere as a means of preventing and treating cancer.

Ellagic acid has also been said to reduce heart disease, birth defects, liver problems, and to promote wound healing.

Ellagic Acid Health Benefits

• Boosts the Immune System
• Reduces the Effects of Aging
• Speeds Healing of Wounds
• Helps Combat Bad Bacteria
• Kills Viruses
• Reduces the Side Effects of Chemotheraphy
• Contains Anti-Cancer Properties
• Slows Tumor Growth
• Antioxidant
• Protects and Defends DNA
• Improves Skin Elasticity
• Protects the Skin Against UV Rays
• Protects the Collagen in the Skin
• Reduces Inflammation

List of Cancer Ellagic Acid May Treat or Prevent:

• Breast
• Cervical
• Colon
• Esophageal
• Leukemia
• Liver
• Lung
• Pancreatic
• Prostate
• Skin
• Tongue

Ellagic Acid Precaution

Eating berries or other natural sources of ellagic acid is generally considered safe. These foods should be part of a balanced diet that includes several servings of fruits and vegetables each day.

Ellagic acid is available in supplement form. Some reports indicate it may affect certain enzymes in the liver, which could alter the way in which some drugs are absorbed. For this reason, people taking medicines or other dietary supplements should talk with their doctors or pharmacists about all their medicines and supplements before taking ellagic acid. The raspberry leaf, or preparations made from it, should be used with caution during pregnancy because it may initiate labor.

Ellagic acid for the most part is free of harmful side effects, however an increase in blood pressure for some patients has been noticed.

If a cancer patient uses ellagic acid during a course of chemotherapy, the reduced side effects caused by Ellagic Acid may encourage the oncologist to increase the dose of chemo. If the patient then decides to stop the Ellagic Acid, for whatever reason, the side effects of chemotherapy can increase and greatly threaten the patients life.

Buy Ellagic Acid Products Online

Ellagic Acid Supplements
http://www.google.com/search?q=ellagic+acid&tbs=shop:1&aq=f

Ellagic Acid Research Links

Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
http://www.ncbi.nlm.nih.gov/pubmed/20691200

Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells.
http://www.ncbi.nlm.nih.gov/pubmed/20559758

Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/20406206

Ellagic acid inhibits lipopolysaccharide-induced expression of enzymes involved in the synthesis of prostaglandin E2 in human monocytes.
http://www.ncbi.nlm.nih.gov/pubmed/19948080

Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells.
http://www.ncbi.nlm.nih.gov/pubmed/18848760

Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/18595134

Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats.
http://www.ncbi.nlm.nih.gov/pubmed/18444155

Antioxidant and apoptosis-inducing activities of ellagic acid.
http://www.ncbi.nlm.nih.gov/pubmed/17094489

Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia).
http://www.ncbi.nlm.nih.gov/pubmed/16848514

Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse.
http://www.ncbi.nlm.nih.gov/pubmed/16800775

The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.
http://www.ncbi.nlm.nih.gov/pubmed/16426830

Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid.
http://www.ncbi.nlm.nih.gov/pubmed/15922998

The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1.
http://www.ncbi.nlm.nih.gov/pubmed/15870380

Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells.
http://www.ncbi.nlm.nih.gov/pubmed/15868936

Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells.
http://www.ncbi.nlm.nih.gov/pubmed/15670891

In vitro anti-proliferative activities of ellagic acid.
http://www.ncbi.nlm.nih.gov/pubmed/15590271

Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice.
http://www.ncbi.nlm.nih.gov/pubmed/19180803

Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells.
http://www.ncbi.nlm.nih.gov/pubmed/12888656

Ellagic [correction of ellagica] acid inhibits arylamine N-acetyltransferase activity and DNA adduct formation in human bladder tumor cell lines (T24 and TSGH 8301).
http://www.ncbi.nlm.nih.gov/pubmed/11828989

p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/10355751

Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity.
http://www.ncbi.nlm.nih.gov/pubmed/10089063